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OK, so apparently lots of people are having difficulty with this since this application was not developed to run in a 64 bit environment.
So, the developers at Microsoft, in their infinite wisdom provided us with "Compatibility Mode."
Here is what I did to get this application to work in XP 64, should be the same for Vista.
1. Download the latest Sprint Media Manager for Instinct.
2. After DL is complete, right click and select properties.
3. Compatibility tab, select "Run this program for: Windows XP"
There, reboot and run!
Easy - VMWare. You'll still need a Windows licence.
I haven't tried SMM under Wine - it may work and that'd be free. If anyone does get that working let us know!